Peregrine Pharmaceuticals Starts Phase III Lung Cancer Trial


Initiates Sunrise Pivotal III Clinical of Bavituximab in Second-Line Non-Small Cell

Company Launches to Assist Patients and Physicians

TUSTIN, CA–(Marketwired – Dec 30, 2013) – Peregrine Pharmaceuticals, Inc. (NASDAQ: PPHM), today announced the opening to enrollment of its SUNRISE trial at leading oncology centers in the United States. SUNRISE is a pivotal Phase III clinical trial comparing the company’s investigational immunotherapy bavituximab plus the chemotherapy docetaxel against placebo plus the chemotherapy docetaxel in patients with second-line non-small cell lung cancer (NSCLC). This trial will enroll approximately 600 patients from more than 100 medical centers worldwide.

“The design of the SUNRISE trial was based on the compelling Phase II data demonstrating encouraging improvement in overall survival in patients with second-line NSCLC. Furthermore, peer-reviewed published data support that bavituximab and docetaxel share highly compatible mechanisms of action that we believe hold promise for improved patient outcomes,”1-6 said Joe Shan, MPH, vice president of clinical and regulatory affairs at Peregrine. “We believe harnessing the body’s natural immune system to fight cancer will be an integral part to conquering this deadly disease. Multiple peer-reviewed published data support bavituximab’s immunotherapy mechanism of action whereby the targeted monoclonal antibody blocks an immune checkpoint responsible for immune suppression at the local tumor environment, thereby allowing the immune system to recognize and fight this deadly disease.”

“This is a significant milestone for the company as patients with advanced non-small cell lung cancer who have progressed on a prior treatment have few therapeutic options, and new approaches to managing their disease are in demand,” said Steven King, chief executive…Read more

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