SIGA Selects Lead Candidate for Dengue Antiviral Program

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NEW YORK, Aug. 1, 2013 (GLOBE NEWSWIRE) — Technologies, Inc. (Nasdaq:) today announced that it has selected a for its fever .

“Identifying a lead candidate is an early but crucial step in a long journey to develop a dengue fever drug,” said Dr. Dennis E. Hruby, SIGA’s Chief Scientific Officer. “Our new, orally bioavailable lead candidate compound appears to have a novel mechanism of action against all four serotypes of dengue virus in vitro at the nanomolar level, and to demonstrate efficacy in mouse models. Having selected a lead preclinical candidate compound, we intend to start scale-up and formulation work as we pursue Investigational New Drug (IND)-enabling studies.”

Dr. Eric A. Rose, SIGA’s Chief Executive Officer, added, “Tens of millions of people around the world contract some form of dengue fever each year, and the geographic reach of the disease appears to be expanding. Even the United States is not immune, with cases documented in three states over the last decade. Ultimately, we believe our work could benefit millions of people, including those living in regions where dengue is endemic, travelers to those regions, and commercial or military personnel deployed in those areas. The recent outbreaks of dengue fever in Africa and Asia underscore the need for an effective antiviral to treat this debilitating disease.”

Research reported in this release was partially supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under Award Number R01AI093356. The content of this press release does not necessarily represent the official views of the National Institutes of Health.

ABOUT DENGUE VIRUS

Dengue fever (DF) is an acute febrile disease, which is characterized by a sudden onset of fever and an abnormally high internal body temperature. One of four closely related virus serotypes (DENV-1, DENV-2, DENV-3, and DENV-4)…Read more

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