First patient dosed in the Phase I/II study of Umecrine Mood’s candidate drug for premenstrual dysphoric disorder

barbara.lempert

STOCKHOLM – May 23, 2013. Mood AB announced today that dosing has been initiated in a randomized of UC1010 for the treatment of patients with (PMDD). Umecrine Mood is part of the Karolinska Development portfolio.

Most women experience some form of symptoms the days before menstruation but in about five percent of young and middle-aged women, the symptoms are so severe that they are considered to be suffering from PMDD. This means that the symptoms in a debilitating way affect daily life and relationships to other people.

“The symptoms occur due to that a breakdown product of a sex hormone affect the brain’s emotional center. Umecrine Mood is the company to successfully develop compounds that are proven to reduce the activity of the breakdown product in healthy individuals. Now we take the next step to evaluate the safety and efficacy of our in patients”, says Karin Ekberg, CEO of Umecrine Mood.

The first has now been dosed with UC1010 in a double-blind, multicenter study in which the safety and efficacy of the product will be evaluated in a total of 120 individuals. Principal Investigator is Professor Marie Bixo, Institute of Clinical Research and Education, Södersjukhuset, Karolinska Institutet.

“The currently available treatment of PMDD is primarily antidepressant drugs, which are not always effective and often cause side effects”, says Torbjörn Bjerke, CEO of Karolinska Development AB. “There is no doubt that these women are in need of an effective and targeted treatment, nor that the health economic benefits of being able to help the patient group would be significant.”

For further information, please contact:

Karin Ekberg, CEO, Umecrine Mood AB

Phone: +46 8 524 844 82, e‐mail: karin.ekberg@umecrine.se

Torbjörn Bjerke, CEO, Karolinska Development AB

Phone…Read more

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